Two probable cases of serious drug interaction between clarithromycin and colchicine

Vincent C.C. Cheng; P. L. Ho; K. Y. Yuen

doi:10.1097/01.SMJ.0000163315.02563.B2

Two probable cases of serious drug interaction between clarithromycin and colchicine

Vincent C.C. Cheng, P. L. Ho, K. Y. Yuen

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin.

Original language	English
Pages (from-to)	811-813
Number of pages	3
Journal	Southern Medical Journal
Volume	98
Issue number	8
DOIs	https://doi.org/10.1097/01.SMJ.0000163315.02563.B2
Publication status	Published - Aug 2005
Externally published	Yes

ASJC Scopus Subject Areas

General Medicine

Keywords

Clarithromycin
Colchicine
Drug-drug interactions

Access to Document

10.1097/01.SMJ.0000163315.02563.B2

Cite this

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title = "Two probable cases of serious drug interaction between clarithromycin and colchicine",

abstract = "Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin.",

keywords = "Clarithromycin, Colchicine, Drug-drug interactions",

author = "Cheng, {Vincent C.C.} and Ho, {P. L.} and Yuen, {K. Y.}",

year = "2005",

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AU - Cheng, Vincent C.C.

AU - Ho, P. L.

AU - Yuen, K. Y.

PY - 2005/8

Y1 - 2005/8

N2 - Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin.

AB - Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin.

KW - Clarithromycin

KW - Colchicine

KW - Drug-drug interactions

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JF - Southern Medical Journal

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ER -

Two probable cases of serious drug interaction between clarithromycin and colchicine

Abstract

ASJC Scopus Subject Areas

Keywords

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