Abstract
In this study, two novel noroviruses (NoVs) were discovered from faecal samples from California sea lions from an oceanarium in Hong Kong, and named California sea lion NoV 1 (Csl/NoV1) and California sea lion NoV 2 (Csl/NoV2). Whole-genome sequencing showed that the genome organization and amino acid motifs of both Csl/NoV1 and Csl/NoV2 were typical of those of other NoVs in their open reading frames (ORFs). Csl/NoV1 possessed only 52.6-52.8 % amino acid identity in VP1 to the closest matches in genogroup GII. Therefore, Csl/NoV1 should constitute a novel genogroup of NoV. Shifting of the phylogenetic position of Csl/NoV1 in the RdRp, VP1 and VP2 trees was observed, which may have been due to recombination events and/or biased mutations. Csl/NoV2 possessed 55.4-56.2 % amino acid identity in VP1 to its closest relatives in genogroup GVI, which means that it represents a new genotype in genogroup GVI. Further studies will reveal what diseases these NoVs can cause in marine mammals.
| Original language | English |
|---|---|
| Article number | 001071 |
| Pages (from-to) | 772-782 |
| Number of pages | 11 |
| Journal | Journal of General Virology |
| Volume | 99 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 The Authors.
ASJC Scopus Subject Areas
- Virology
Keywords
- California sea lions
- Genogroup
- Noroviruses
- Novel