Transferable hyperproduction of TEM-1 β-lactamase in Shigella flexneri due to a point mutation in the pribnow box

L. K. Siu; P. L. Ho; K. Y. Yuen; S. S.Y. Wong; P. Y. Chau

doi:10.1128/aac.41.2.468

Transferable hyperproduction of TEM-1 β-lactamase in Shigella flexneri due to a point mutation in the pribnow box

L. K. Siu, P. L. Ho, K. Y. Yuen, S. S.Y. Wong, P. Y. Chau

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the bla(TEM) gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G→T transversion at position 1 of the - 10 consensus sequence was identified to be the mechanism of TEM-1 hyperproduction.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	41
Issue number	2
DOIs	https://doi.org/10.1128/aac.41.2.468
Publication status	Published - 1997
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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AU - Wong, S. S.Y.

AU - Chau, P. Y.

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AB - TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the bla(TEM) gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G→T transversion at position 1 of the - 10 consensus sequence was identified to be the mechanism of TEM-1 hyperproduction.

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Transferable hyperproduction of TEM-1 β-lactamase in Shigella flexneri due to a point mutation in the pribnow box

Abstract

ASJC Scopus Subject Areas

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