SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong

Rosana Wing Shan Poon; Brian Pui Chun Chan; Wan Mui Chan; Carol Ho Yan Fong; Xiaojuan Zhang; Lu Lu; Lin Lei Chen; Joy Yan Lam; Vincent Chi Chung Cheng; Samson S.Y. Wong; Kin Hang Kok; Kwok Yung Yuen; Kelvin Kai Wang To

doi:10.1080/22221751.2022.2106899

SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong

Rosana Wing Shan Poon, Brian Pui Chun Chan, Wan Mui Chan, Carol Ho Yan Fong, Xiaojuan Zhang, Lu Lu, Lin Lei Chen, Joy Yan Lam, Vincent Chi Chung Cheng, Samson S.Y. Wong, Kin Hang Kok, Kwok Yung Yuen, Kelvin Kai Wang To

Research output: Contribution to journal › Letter › peer-review

18 Citations (Scopus)

Abstract

The SARS-CoV-2 Omicron variant has led to a major wave of COVID-19 in Hong Kong between January and May 2022. Here, we used seroprevalence to estimate the combined incidence of vaccination and SARS-CoV-2 infection, including subclinical infection which were not diagnosed at the acute stage. The overall seropositive rate of IgG against receptor binding domain (anti-RBD IgG) increased from 52.2% in December 2021 to 89.3% in May 2022. The level of anti-RBD IgG was lowest in the 0–9 and ≥80 year-old age groups in May 2022. The seropositive rate of antibody against ORF8, which reflects the rate of prior infection, was 23.4% in May 2022. Our data suggest that although most individuals were either vaccinated or infected after the fifth wave, children and older adults remain most vulnerable. Public health measures should target these age groups in order to ameliorate the healthcare consequences of upcoming waves.

Original language	English
Pages (from-to)	2116-2119
Number of pages	4
Journal	Emerging Microbes and Infections
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/22221751.2022.2106899
Publication status	Published - 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

ASJC Scopus Subject Areas

Epidemiology
Parasitology
Microbiology
Immunology
Drug Discovery
Infectious Diseases
Virology

Keywords

COVID-19
nucleoprotein
ORF8
receptor binding domain
SARS-CoV-2
serosurveillance

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10.1080/22221751.2022.2106899

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abstract = "The SARS-CoV-2 Omicron variant has led to a major wave of COVID-19 in Hong Kong between January and May 2022. Here, we used seroprevalence to estimate the combined incidence of vaccination and SARS-CoV-2 infection, including subclinical infection which were not diagnosed at the acute stage. The overall seropositive rate of IgG against receptor binding domain (anti-RBD IgG) increased from 52.2% in December 2021 to 89.3% in May 2022. The level of anti-RBD IgG was lowest in the 0–9 and ≥80 year-old age groups in May 2022. The seropositive rate of antibody against ORF8, which reflects the rate of prior infection, was 23.4% in May 2022. Our data suggest that although most individuals were either vaccinated or infected after the fifth wave, children and older adults remain most vulnerable. Public health measures should target these age groups in order to ameliorate the healthcare consequences of upcoming waves.",

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doi = "10.1080/22221751.2022.2106899",

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AU - Chan, Brian Pui Chun

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AU - Fong, Carol Ho Yan

AU - Zhang, Xiaojuan

AU - Lu, Lu

AU - Chen, Lin Lei

AU - Lam, Joy Yan

AU - Cheng, Vincent Chi Chung

AU - Wong, Samson S.Y.

AU - Kok, Kin Hang

AU - Yuen, Kwok Yung

AU - To, Kelvin Kai Wang

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AB - The SARS-CoV-2 Omicron variant has led to a major wave of COVID-19 in Hong Kong between January and May 2022. Here, we used seroprevalence to estimate the combined incidence of vaccination and SARS-CoV-2 infection, including subclinical infection which were not diagnosed at the acute stage. The overall seropositive rate of IgG against receptor binding domain (anti-RBD IgG) increased from 52.2% in December 2021 to 89.3% in May 2022. The level of anti-RBD IgG was lowest in the 0–9 and ≥80 year-old age groups in May 2022. The seropositive rate of antibody against ORF8, which reflects the rate of prior infection, was 23.4% in May 2022. Our data suggest that although most individuals were either vaccinated or infected after the fifth wave, children and older adults remain most vulnerable. Public health measures should target these age groups in order to ameliorate the healthcare consequences of upcoming waves.

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SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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