Re-emergence of fatal human influenza A subtype H5N1 disease

J. S.M. Peiris; W. C. Yu; C. W. Leung; C. Y. Cheung; W. F. Ng; J. M. Nicholls; T. K. Ng; K. H. Chan; S. T. Lai; W. L. Lim; K. Y. Yuen; Y. Guan

doi:10.1016/S0140-6736(04)15595-5

Re-emergence of fatal human influenza A subtype H5N1 disease

J. S.M. Peiris, W. C. Yu, C. W. Leung, C. Y. Cheung, W. F. Ng, J. M. Nicholls, T. K. Ng, K. H. Chan, S. T. Lai, W. L. Lim, K. Y. Yuen, Y. Guan

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721 Citations (Scopus)

Abstract

Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.

Original language	English
Pages (from-to)	617-619
Number of pages	3
Journal	Lancet
Volume	363
Issue number	9409
DOIs	https://doi.org/10.1016/S0140-6736(04)15595-5
Publication status	Published - Feb 21 2004
Externally published	Yes

ASJC Scopus Subject Areas

General Medicine

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10.1016/S0140-6736(04)15595-5

Cite this

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title = "Re-emergence of fatal human influenza A subtype H5N1 disease",

abstract = "Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.",

author = "Peiris, {J. S.M.} and Yu, {W. C.} and Leung, {C. W.} and Cheung, {C. Y.} and Ng, {W. F.} and Nicholls, {J. M.} and Ng, {T. K.} and Chan, {K. H.} and Lai, {S. T.} and Lim, {W. L.} and Yuen, {K. Y.} and Y. Guan",

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TY - JOUR

T1 - Re-emergence of fatal human influenza A subtype H5N1 disease

AU - Peiris, J. S.M.

AU - Yu, W. C.

AU - Leung, C. W.

AU - Cheung, C. Y.

AU - Ng, W. F.

AU - Nicholls, J. M.

AU - Ng, T. K.

AU - Chan, K. H.

AU - Lai, S. T.

AU - Lim, W. L.

AU - Yuen, K. Y.

AU - Guan, Y.

PY - 2004/2/21

Y1 - 2004/2/21

N2 - Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.

AB - Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.

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SP - 617

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JO - Lancet

JF - Lancet

IS - 9409

ER -

Re-emergence of fatal human influenza A subtype H5N1 disease

Abstract

ASJC Scopus Subject Areas

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