Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections

Bo Jian Zheng; Xiu Ying Zhao; Nai Shuo Zhu; Ching Ping Chan; Ka Hing Wong; Kenny Chi-Wai Chan; Wing Cheong Yam; Kwok Yung Yuen; Shui Shan Lee

doi:10.1097/00002030-200212060-00016

Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections

Bo Jian Zheng, Xiu Ying Zhao, Nai Shuo Zhu, Ching Ping Chan, Ka Hing Wong, Kenny Chi-Wai Chan, Wing Cheong Yam, Kwok Yung Yuen, Shui Shan Lee

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Seven mutant alleles of the CCR5 gene were identified in southern Chinese, six of which were novel mutations. The most common was a heterozygous mutant allele (R223Q) found in 21 healthy donors and 20 HIV patients. No significant difference in the mutant frequency was observed between healthy donors (0.044) and HIV patients (0.041), but the frequency was significantly higher in asymptomatic (0.066) than in symptomatic HIV patients (0.019).

Original language	English
Pages (from-to)	2480-2482
Number of pages	3
Journal	AIDS
Volume	16
Issue number	18
DOIs	https://doi.org/10.1097/00002030-200212060-00016
Publication status	Published - Dec 6 2002
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Infectious Diseases

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title = "Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections",

abstract = "Seven mutant alleles of the CCR5 gene were identified in southern Chinese, six of which were novel mutations. The most common was a heterozygous mutant allele (R223Q) found in 21 healthy donors and 20 HIV patients. No significant difference in the mutant frequency was observed between healthy donors (0.044) and HIV patients (0.041), but the frequency was significantly higher in asymptomatic (0.066) than in symptomatic HIV patients (0.019).",

author = "Zheng, {Bo Jian} and Zhao, {Xiu Ying} and Zhu, {Nai Shuo} and Chan, {Ching Ping} and Wong, {Ka Hing} and {Chi-Wai Chan}, Kenny and Yam, {Wing Cheong} and Yuen, {Kwok Yung} and Lee, {Shui Shan}",

year = "2002",

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day = "6",

doi = "10.1097/00002030-200212060-00016",

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pages = "2480--2482",

journal = "AIDS",

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TY - JOUR

T1 - Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections

AU - Zheng, Bo Jian

AU - Zhao, Xiu Ying

AU - Zhu, Nai Shuo

AU - Chan, Ching Ping

AU - Wong, Ka Hing

AU - Chi-Wai Chan, Kenny

AU - Yam, Wing Cheong

AU - Yuen, Kwok Yung

AU - Lee, Shui Shan

PY - 2002/12/6

Y1 - 2002/12/6

N2 - Seven mutant alleles of the CCR5 gene were identified in southern Chinese, six of which were novel mutations. The most common was a heterozygous mutant allele (R223Q) found in 21 healthy donors and 20 HIV patients. No significant difference in the mutant frequency was observed between healthy donors (0.044) and HIV patients (0.041), but the frequency was significantly higher in asymptomatic (0.066) than in symptomatic HIV patients (0.019).

AB - Seven mutant alleles of the CCR5 gene were identified in southern Chinese, six of which were novel mutations. The most common was a heterozygous mutant allele (R223Q) found in 21 healthy donors and 20 HIV patients. No significant difference in the mutant frequency was observed between healthy donors (0.044) and HIV patients (0.041), but the frequency was significantly higher in asymptomatic (0.066) than in symptomatic HIV patients (0.019).

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UR - http://www.scopus.com/inward/citedby.url?scp=0037032906&partnerID=8YFLogxK

U2 - 10.1097/00002030-200212060-00016

DO - 10.1097/00002030-200212060-00016

M3 - Article

C2 - 12461425

AN - SCOPUS:0037032906

SN - 0269-9370

VL - 16

SP - 2480

EP - 2482

JO - AIDS

JF - AIDS

IS - 18

ER -

Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections

Abstract

ASJC Scopus Subject Areas

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