TY - JOUR
T1 - Obesity indicators as mediators of association between daytime napping and type 2 diabetes mellitus
T2 - the Guangzhou Biobank Cohort Study
AU - Xiao, Jing Yi
AU - Zhang, Wei Sen
AU - Jiang, Chao Qiang
AU - Jin, Ya Li
AU - Zhu, Feng
AU - Cheng, Kar Keung
AU - Lam, Tai Hing
AU - Xu, Lin
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Objective: To examine the mediating effect of obesity indicators on the association between daytime napping and type 2 diabetes mellitus (T2DM) qualitatively and quantitatively using baseline data from the Guangzhou Biobank Cohort Study. Methods: Twenty-nine thousand three hundred fifty-five participants aged 50+ years were included in this cross-sectional study. Mediation analysis was used to assess the mediating effect of body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) on the association between daytime napping and T2DM after adjustment for sex, age, education, occupation, smoking status, alcohol use and physical activity. Results: The mean (standard deviation) age of participants was 61.5 (7.1) years. The prevalence of T2DM and daytime napping was 12.5% and 65.2%, respectively. After adjustment for potential confounders, WC, WHR and WHtR showed partial mediating effects on the association between daytime napping and T2DM, with the proportion (95% confidence interval) of mediation effect being 10.17% (8.14–14.43%), 14.91% (11.95–21.24%) and 9.36% (7.49–13.29%), respectively. No mediating effect of BMI or HC on the association between daytime napping and T2DM was found. Conclusions: Our results showed significant mediating effects of WC, WHR and WHtR on the association between daytime napping and T2DM, suggesting that waist circumference management could be important in daytime nappers.
AB - Objective: To examine the mediating effect of obesity indicators on the association between daytime napping and type 2 diabetes mellitus (T2DM) qualitatively and quantitatively using baseline data from the Guangzhou Biobank Cohort Study. Methods: Twenty-nine thousand three hundred fifty-five participants aged 50+ years were included in this cross-sectional study. Mediation analysis was used to assess the mediating effect of body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) on the association between daytime napping and T2DM after adjustment for sex, age, education, occupation, smoking status, alcohol use and physical activity. Results: The mean (standard deviation) age of participants was 61.5 (7.1) years. The prevalence of T2DM and daytime napping was 12.5% and 65.2%, respectively. After adjustment for potential confounders, WC, WHR and WHtR showed partial mediating effects on the association between daytime napping and T2DM, with the proportion (95% confidence interval) of mediation effect being 10.17% (8.14–14.43%), 14.91% (11.95–21.24%) and 9.36% (7.49–13.29%), respectively. No mediating effect of BMI or HC on the association between daytime napping and T2DM was found. Conclusions: Our results showed significant mediating effects of WC, WHR and WHtR on the association between daytime napping and T2DM, suggesting that waist circumference management could be important in daytime nappers.
KW - Daytime napping
KW - Mediation analysis
KW - Obesity
KW - Type 2 diabetes mellitus
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U2 - 10.1186/s12889-021-12451-8
DO - 10.1186/s12889-021-12451-8
M3 - Article
C2 - 35012516
AN - SCOPUS:85122700060
SN - 1472-698X
VL - 22
JO - BMC Public Health
JF - BMC Public Health
IS - 1
M1 - 56
ER -