Novel betacoronavirus in dromedaries of the Middle East, 2013

Patrick C.Y. Woo; Susanna K.P. Lau; Ulrich Wernery; Emily Y.M. Wong; Alan K.L. Tsang; Bobby Johnson; Cyril C.Y. Yip; Candy C.Y. Lau; Saritha Sivakumar; Jian Piao Cai; Rachel Y.Y. Fan; Kwok Hung Chan; Ringu Mareena; Kwok Yung Yuen

doi:10.3201/eid2004.131769

Novel betacoronavirus in dromedaries of the Middle East, 2013

Patrick C.Y. Woo, Susanna K.P. Lau, Ulrich Wernery, Emily Y.M. Wong, Alan K.L. Tsang, Bobby Johnson, Cyril C.Y. Yip, Candy C.Y. Lau, Saritha Sivakumar, Jian Piao Cai, Rachel Y.Y. Fan, Kwok Hung Chan, Ringu Mareena, Kwok Yung Yuen

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAEHKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.

Original language	English
Pages (from-to)	560-572
Number of pages	13
Journal	Emerging Infectious Diseases
Volume	20
Issue number	4
DOIs	https://doi.org/10.3201/eid2004.131769
Publication status	Published - Apr 2014
Externally published	Yes

ASJC Scopus Subject Areas

Epidemiology
Microbiology (medical)
Infectious Diseases

Access to Document

10.3201/eid2004.131769

Cite this

@article{01a2177c7fe641d0916b54d875fb423f,

title = "Novel betacoronavirus in dromedaries of the Middle East, 2013",

abstract = "In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAEHKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.",

author = "Woo, {Patrick C.Y.} and Lau, {Susanna K.P.} and Ulrich Wernery and Wong, {Emily Y.M.} and Tsang, {Alan K.L.} and Bobby Johnson and Yip, {Cyril C.Y.} and Lau, {Candy C.Y.} and Saritha Sivakumar and Cai, {Jian Piao} and Fan, {Rachel Y.Y.} and Chan, {Kwok Hung} and Ringu Mareena and Yuen, {Kwok Yung}",

year = "2014",

month = apr,

doi = "10.3201/eid2004.131769",

language = "English",

volume = "20",

pages = "560--572",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "4",

}

TY - JOUR

T1 - Novel betacoronavirus in dromedaries of the Middle East, 2013

AU - Woo, Patrick C.Y.

AU - Lau, Susanna K.P.

AU - Wernery, Ulrich

AU - Wong, Emily Y.M.

AU - Tsang, Alan K.L.

AU - Johnson, Bobby

AU - Yip, Cyril C.Y.

AU - Lau, Candy C.Y.

AU - Sivakumar, Saritha

AU - Cai, Jian Piao

AU - Fan, Rachel Y.Y.

AU - Chan, Kwok Hung

AU - Mareena, Ringu

AU - Yuen, Kwok Yung

PY - 2014/4

Y1 - 2014/4

N2 - In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAEHKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.

AB - In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAEHKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.

UR - http://www.scopus.com/inward/record.url?scp=84896448668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896448668&partnerID=8YFLogxK

U2 - 10.3201/eid2004.131769

DO - 10.3201/eid2004.131769

M3 - Article

C2 - 24655427

AN - SCOPUS:84896448668

SN - 1080-6040

VL - 20

SP - 560

EP - 572

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 4

ER -

Novel betacoronavirus in dromedaries of the Middle East, 2013

Abstract

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this