Neurosensory rehabilitation and olfactory network recovery in COVID-19-related olfactory dysfunction

Tom Wai Hin Chung; Hui Zhang; Fergus Kai Chuen Wong; Siddharth Sridhar; Kwok Hung Chan; Vincent Chi Chung Cheng; Kwok Yung Yuen; Ivan Fan Ngai Hung; Henry Ka Fung Mak

doi:10.3390/brainsci11060686

Neurosensory rehabilitation and olfactory network recovery in COVID-19-related olfactory dysfunction

Tom Wai Hin Chung, Hui Zhang, Fergus Kai Chuen Wong, Siddharth Sridhar, Kwok Hung Chan, Vincent Chi Chung Cheng, Kwok Yung Yuen, Ivan Fan Ngai Hung, Henry Ka Fung Mak

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm³ to 49.5 mm³ (120%), left: 37.5 mm3 to 42 mm³ (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].

Original language	English
Article number	686
Journal	Brain Sciences
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/brainsci11060686
Publication status	Published - Jun 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

General Neuroscience

Keywords

COVID-19
Olfactory dysfunction
Resting-state fMRI
Smell training
Vitamin A

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title = "Neurosensory rehabilitation and olfactory network recovery in COVID-19-related olfactory dysfunction",

abstract = "Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm3 to 49.5 mm3 (120%), left: 37.5 mm3 to 42 mm3 (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].",

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author = "Chung, {Tom Wai Hin} and Hui Zhang and Wong, {Fergus Kai Chuen} and Siddharth Sridhar and Chan, {Kwok Hung} and Cheng, {Vincent Chi Chung} and Yuen, {Kwok Yung} and Hung, {Ivan Fan Ngai} and Mak, {Henry Ka Fung}",

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AU - Chung, Tom Wai Hin

AU - Zhang, Hui

AU - Wong, Fergus Kai Chuen

AU - Sridhar, Siddharth

AU - Chan, Kwok Hung

AU - Cheng, Vincent Chi Chung

AU - Yuen, Kwok Yung

AU - Hung, Ivan Fan Ngai

AU - Mak, Henry Ka Fung

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Y1 - 2021/6

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AB - Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm3 to 49.5 mm3 (120%), left: 37.5 mm3 to 42 mm3 (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].

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KW - Resting-state fMRI

KW - Smell training

KW - Vitamin A

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Neurosensory rehabilitation and olfactory network recovery in COVID-19-related olfactory dysfunction

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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