Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae

Patrick C.Y. Woo; Susanna K.P. Lau; Garnet K.Y. Choi; Yi Huang; Saritha Sivakumar; Hoi Wah Tsoi; Cyril C.Y. Yip; Shanty V. Jose; Ru Bai; Emily Y.M. Wong; Marina Joseph; Tong Li; Ulrich Wernery; Kwok Yung Yuen

doi:10.1016/j.meegid.2016.03.033

Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae

Patrick C.Y. Woo, Susanna K.P. Lau, Garnet K.Y. Choi, Yi Huang, Saritha Sivakumar, Hoi Wah Tsoi, Cyril C.Y. Yip, Shanty V. Jose, Ru Bai, Emily Y.M. Wong, Marina Joseph, Tong Li, Ulrich Wernery, Kwok Yung Yuen

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Previously, we reported the discovery of a novel canine picornavirus (CanPV) in the fecal sample of a dog. In this molecular epidemiology study, CanPV was detected in 15 (1.11%) of 1347 canine fecal samples from Hong Kong and one (0.76%) of 131 canine fecal samples from Dubai, with viral loads 1.06×10³ to 6.64×10⁶ copies/ml. Complete genome sequencing and phylogenetic analysis showed that CanPV was clustered with feline picornavirus (FePV), bat picornavirus (BatPV) 1 to 3, Ia io picornavirus 1 (IaioPV1) and bovine picornavirus (BoPV), and this cluster was most closely related to the genera Enterovirus and Sapelovirus. The Ka/Ks ratios of all the coding regions were <0.1. According to the definition of the Picornavirus Study Group of ICTV, CanPV, FePV, BatPV 1 to 3, IaioPV1 and BoPV should constitute a novel genus in Picornaviridae. BEAST analysis showed that this genus diverged from its most closely related genus, Sapelovirus, about 49 years ago.

Original language	English
Pages (from-to)	191-200
Number of pages	10
Journal	Infection, Genetics and Evolution
Volume	41
DOIs	https://doi.org/10.1016/j.meegid.2016.03.033
Publication status	Published - Jul 1 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.

ASJC Scopus Subject Areas

Microbiology
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
Microbiology (medical)
Infectious Diseases

Keywords

Animal RNA viruses
Dog
Picornavirus

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10.1016/j.meegid.2016.03.033

Cite this

Woo, P. C. Y., Lau, S. K. P., Choi, G. K. Y., Huang, Y., Sivakumar, S., Tsoi, H. W., Yip, C. C. Y., Jose, S. V., Bai, R., Wong, E. Y. M., Joseph, M., Li, T., Wernery, U., & Yuen, K. Y. (2016). Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae. Infection, Genetics and Evolution, 41, 191-200. https://doi.org/10.1016/j.meegid.2016.03.033

Woo, PCY, Lau, SKP, Choi, GKY, Huang, Y, Sivakumar, S, Tsoi, HW, Yip, CCY, Jose, SV, Bai, R, Wong, EYM, Joseph, M, Li, T, Wernery, U & Yuen, KY 2016, 'Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae', Infection, Genetics and Evolution, vol. 41, pp. 191-200. https://doi.org/10.1016/j.meegid.2016.03.033

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abstract = "Previously, we reported the discovery of a novel canine picornavirus (CanPV) in the fecal sample of a dog. In this molecular epidemiology study, CanPV was detected in 15 (1.11%) of 1347 canine fecal samples from Hong Kong and one (0.76%) of 131 canine fecal samples from Dubai, with viral loads 1.06×103 to 6.64×106 copies/ml. Complete genome sequencing and phylogenetic analysis showed that CanPV was clustered with feline picornavirus (FePV), bat picornavirus (BatPV) 1 to 3, Ia io picornavirus 1 (IaioPV1) and bovine picornavirus (BoPV), and this cluster was most closely related to the genera Enterovirus and Sapelovirus. The Ka/Ks ratios of all the coding regions were <0.1. According to the definition of the Picornavirus Study Group of ICTV, CanPV, FePV, BatPV 1 to 3, IaioPV1 and BoPV should constitute a novel genus in Picornaviridae. BEAST analysis showed that this genus diverged from its most closely related genus, Sapelovirus, about 49 years ago.",

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Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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