Molecular diversity of coronaviruses in bats

Patrick C.Y. Woo; Susanna K.P. Lau; Kenneth S.M. Li; Rosana W.S. Poon; Beatrice H.L. Wong; Hoi wah Tsoi; Bethanie C.K. Yip; Yi Huang; Kwok hung Chan; Kwok yung Yuen

doi:10.1016/j.virol.2006.02.041

Molecular diversity of coronaviruses in bats

Patrick C.Y. Woo, Susanna K.P. Lau, Kenneth S.M. Li, Rosana W.S. Poon, Beatrice H.L. Wong, Hoi wah Tsoi, Bethanie C.K. Yip, Yi Huang, Kwok hung Chan, Kwok yung Yuen

Research output: Contribution to journal › Article › peer-review

266 Citations (Scopus)

Abstract

The existence of coronaviruses in bats is unknown until the recent discovery of bat-SARS-CoV in Chinese horseshoe bats and a novel group 1 coronavirus in other bat species. Among 309 bats of 13 species captured from 20 different locations in rural areas of Hong Kong over a 16-month period, coronaviruses were amplified from anal swabs of 37 (12%) bats by RT-PCR. Phylogenetic analysis of RNA-dependent-RNA-polymerase (pol) and helicase genes revealed six novel coronaviruses from six different bat species, in addition to the two previously described coronaviruses. Among the six novel coronaviruses, four were group 1 coronaviruses (bat-CoV HKU2 from Chinese horseshoe bat, bat-CoV HKU6 from rickett's big-footed bat, bat-CoV HKU7 from greater bent-winged bat and bat-CoV HKU8 from lesser bent-winged bat) and two were group 2 coronaviruses (bat-CoV HKU4 from lesser bamboo bats and bat-CoV HKU5 from Japanese pipistrelles). An astonishing diversity of coronaviruses was observed in bats.

Original language	English
Pages (from-to)	180-187
Number of pages	8
Journal	Virology
Volume	351
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2006.02.041
Publication status	Published - Jul 20 2006
Externally published	Yes

ASJC Scopus Subject Areas

Virology

Keywords

Bats
Coronavirus
Diversity

Access to Document

10.1016/j.virol.2006.02.041

Cite this

@article{dd8628acebdc41ae9e89f4884c475567,

title = "Molecular diversity of coronaviruses in bats",

abstract = "The existence of coronaviruses in bats is unknown until the recent discovery of bat-SARS-CoV in Chinese horseshoe bats and a novel group 1 coronavirus in other bat species. Among 309 bats of 13 species captured from 20 different locations in rural areas of Hong Kong over a 16-month period, coronaviruses were amplified from anal swabs of 37 (12%) bats by RT-PCR. Phylogenetic analysis of RNA-dependent-RNA-polymerase (pol) and helicase genes revealed six novel coronaviruses from six different bat species, in addition to the two previously described coronaviruses. Among the six novel coronaviruses, four were group 1 coronaviruses (bat-CoV HKU2 from Chinese horseshoe bat, bat-CoV HKU6 from rickett's big-footed bat, bat-CoV HKU7 from greater bent-winged bat and bat-CoV HKU8 from lesser bent-winged bat) and two were group 2 coronaviruses (bat-CoV HKU4 from lesser bamboo bats and bat-CoV HKU5 from Japanese pipistrelles). An astonishing diversity of coronaviruses was observed in bats.",

keywords = "Bats, Coronavirus, Diversity",

author = "Woo, {Patrick C.Y.} and Lau, {Susanna K.P.} and Li, {Kenneth S.M.} and Poon, {Rosana W.S.} and Wong, {Beatrice H.L.} and Tsoi, {Hoi wah} and Yip, {Bethanie C.K.} and Yi Huang and Chan, {Kwok hung} and Yuen, {Kwok yung}",

year = "2006",

month = jul,

day = "20",

doi = "10.1016/j.virol.2006.02.041",

language = "English",

volume = "351",

pages = "180--187",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Molecular diversity of coronaviruses in bats

AU - Woo, Patrick C.Y.

AU - Lau, Susanna K.P.

AU - Li, Kenneth S.M.

AU - Poon, Rosana W.S.

AU - Wong, Beatrice H.L.

AU - Tsoi, Hoi wah

AU - Yip, Bethanie C.K.

AU - Huang, Yi

AU - Chan, Kwok hung

AU - Yuen, Kwok yung

PY - 2006/7/20

Y1 - 2006/7/20

N2 - The existence of coronaviruses in bats is unknown until the recent discovery of bat-SARS-CoV in Chinese horseshoe bats and a novel group 1 coronavirus in other bat species. Among 309 bats of 13 species captured from 20 different locations in rural areas of Hong Kong over a 16-month period, coronaviruses were amplified from anal swabs of 37 (12%) bats by RT-PCR. Phylogenetic analysis of RNA-dependent-RNA-polymerase (pol) and helicase genes revealed six novel coronaviruses from six different bat species, in addition to the two previously described coronaviruses. Among the six novel coronaviruses, four were group 1 coronaviruses (bat-CoV HKU2 from Chinese horseshoe bat, bat-CoV HKU6 from rickett's big-footed bat, bat-CoV HKU7 from greater bent-winged bat and bat-CoV HKU8 from lesser bent-winged bat) and two were group 2 coronaviruses (bat-CoV HKU4 from lesser bamboo bats and bat-CoV HKU5 from Japanese pipistrelles). An astonishing diversity of coronaviruses was observed in bats.

AB - The existence of coronaviruses in bats is unknown until the recent discovery of bat-SARS-CoV in Chinese horseshoe bats and a novel group 1 coronavirus in other bat species. Among 309 bats of 13 species captured from 20 different locations in rural areas of Hong Kong over a 16-month period, coronaviruses were amplified from anal swabs of 37 (12%) bats by RT-PCR. Phylogenetic analysis of RNA-dependent-RNA-polymerase (pol) and helicase genes revealed six novel coronaviruses from six different bat species, in addition to the two previously described coronaviruses. Among the six novel coronaviruses, four were group 1 coronaviruses (bat-CoV HKU2 from Chinese horseshoe bat, bat-CoV HKU6 from rickett's big-footed bat, bat-CoV HKU7 from greater bent-winged bat and bat-CoV HKU8 from lesser bent-winged bat) and two were group 2 coronaviruses (bat-CoV HKU4 from lesser bamboo bats and bat-CoV HKU5 from Japanese pipistrelles). An astonishing diversity of coronaviruses was observed in bats.

KW - Bats

KW - Coronavirus

KW - Diversity

UR - http://www.scopus.com/inward/record.url?scp=33745784140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745784140&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2006.02.041

DO - 10.1016/j.virol.2006.02.041

M3 - Article

C2 - 16647731

AN - SCOPUS:33745784140

SN - 0042-6822

VL - 351

SP - 180

EP - 187

JO - Virology

JF - Virology

IS - 1

ER -

Molecular diversity of coronaviruses in bats

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Cite this