Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: Identification of a novel mutation in inhA

E. T.Y. Leung; P. L. Ho; K. Y. Yuen; W. L. Woo; T. H. Lam; R. Y. Kao; W. H. Seto; W. C. Yam

doi:10.1128/AAC.50.3.1075-1078.2006

Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: Identification of a novel mutation in inhA

E. T.Y. Leung, P. L. Ho, K. Y. Yuen, W. L. Woo, T. H. Lam, R. Y. Kao, W. H. Seto, W. C. Yam

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

Original language	English
Pages (from-to)	1075-1078
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	3
DOIs	https://doi.org/10.1128/AAC.50.3.1075-1078.2006
Publication status	Published - Mar 2006
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.50.3.1075-1078.2006

Cite this

@article{b8eb12870d3a4cc9bc8aa631380afbad,

title = "Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: Identification of a novel mutation in inhA",

abstract = "Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.",

author = "Leung, {E. T.Y.} and Ho, {P. L.} and Yuen, {K. Y.} and Woo, {W. L.} and Lam, {T. H.} and Kao, {R. Y.} and Seto, {W. H.} and Yam, {W. C.}",

year = "2006",

month = mar,

doi = "10.1128/AAC.50.3.1075-1078.2006",

language = "English",

volume = "50",

pages = "1075--1078",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "3",

}

TY - JOUR

T1 - Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis

T2 - Identification of a novel mutation in inhA

AU - Leung, E. T.Y.

AU - Ho, P. L.

AU - Yuen, K. Y.

AU - Woo, W. L.

AU - Lam, T. H.

AU - Kao, R. Y.

AU - Seto, W. H.

AU - Yam, W. C.

PY - 2006/3

Y1 - 2006/3

N2 - Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

AB - Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

UR - http://www.scopus.com/inward/record.url?scp=33644680148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644680148&partnerID=8YFLogxK

U2 - 10.1128/AAC.50.3.1075-1078.2006

DO - 10.1128/AAC.50.3.1075-1078.2006

M3 - Article

C2 - 16495272

AN - SCOPUS:33644680148

SN - 0066-4804

VL - 50

SP - 1075

EP - 1078

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: Identification of a novel mutation in inhA

Abstract

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this