Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene

Kelvin K.W. To; Vincent C.C. Cheng; Jasper F.W. Chan; Amy C.Y. Wong; Sandy Chau; Flora H.F. Tsang; Shirly O.T. Curreem; Susanna K.P. Lau; Kwok Yung Yuen; Patrick C.Y. Woo

doi:10.1128/JCM.00849-11

Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene

Kelvin K.W. To, Vincent C.C. Cheng, Jasper F.W. Chan, Amy C.Y. Wong, Sandy Chau, Flora H.F. Tsang, Shirly O.T. Curreem, Susanna K.P. Lau, Kwok Yung Yuen, Patrick C.Y. Woo

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis.

Original language	English
Pages (from-to)	3398-3402
Number of pages	5
Journal	Journal of Clinical Microbiology
Volume	49
Issue number	9
DOIs	https://doi.org/10.1128/JCM.00849-11
Publication status	Published - Sept 2011
Externally published	Yes

ASJC Scopus Subject Areas

Microbiology (medical)

Access to Document

10.1128/JCM.00849-11

Cite this

To, K. K. W., Cheng, V. C. C., Chan, J. F. W., Wong, A. C. Y., Chau, S., Tsang, F. H. F., Curreem, S. O. T., Lau, S. K. P., Yuen, K. Y., & Woo, P. C. Y. (2011). Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene. Journal of Clinical Microbiology, 49(9), 3398-3402. https://doi.org/10.1128/JCM.00849-11

Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene. / To, Kelvin K.W.; Cheng, Vincent C.C.; Chan, Jasper F.W. et al.
In: Journal of Clinical Microbiology, Vol. 49, No. 9, 09.2011, p. 3398-3402.

Research output: Contribution to journal › Article › peer-review

To, KKW, Cheng, VCC, Chan, JFW, Wong, ACY, Chau, S, Tsang, FHF, Curreem, SOT, Lau, SKP, Yuen, KY & Woo, PCY 2011, 'Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene', Journal of Clinical Microbiology, vol. 49, no. 9, pp. 3398-3402. https://doi.org/10.1128/JCM.00849-11

@article{91f6f396d037422caaea019756b8fb46,

title = "Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene",

abstract = "We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis.",

author = "To, {Kelvin K.W.} and Cheng, {Vincent C.C.} and Chan, {Jasper F.W.} and Wong, {Amy C.Y.} and Sandy Chau and Tsang, {Flora H.F.} and Curreem, {Shirly O.T.} and Lau, {Susanna K.P.} and Yuen, {Kwok Yung} and Woo, {Patrick C.Y.}",

year = "2011",

month = sep,

doi = "10.1128/JCM.00849-11",

language = "English",

volume = "49",

pages = "3398--3402",

journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene

AU - To, Kelvin K.W.

AU - Cheng, Vincent C.C.

AU - Chan, Jasper F.W.

AU - Wong, Amy C.Y.

AU - Chau, Sandy

AU - Tsang, Flora H.F.

AU - Curreem, Shirly O.T.

AU - Lau, Susanna K.P.

AU - Yuen, Kwok Yung

AU - Woo, Patrick C.Y.

PY - 2011/9

Y1 - 2011/9

N2 - We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis.

AB - We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis.

UR - http://www.scopus.com/inward/record.url?scp=80052202334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052202334&partnerID=8YFLogxK

U2 - 10.1128/JCM.00849-11

DO - 10.1128/JCM.00849-11

M3 - Article

C2 - 21715584

AN - SCOPUS:80052202334

SN - 0095-1137

VL - 49

SP - 3398

EP - 3402

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 9

ER -

Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene

Abstract

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this