Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China

Y. Guan; B. J. Zheng; Y. Q. He; X. L. Liu; Z. X. Zhuang; C. L. Cheung; S. W. Luo; P. H. Li; L. J. Zhang; Y. J. Guan; K. M. Butt; K. L. Wong; K. W. Chan; W. Lim; K. F. Shortridge; K. Y. Yuen; J. S.M. Peiris; L. L.M. Poon

doi:10.1126/science.1087139

Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China

Y. Guan, B. J. Zheng, Y. Q. He, X. L. Liu, Z. X. Zhuang, C. L. Cheung, S. W. Luo, P. H. Li, L. J. Zhang, Y. J. Guan, K. M. Butt, K. L. Wong, K. W. Chan, W. Lim, K. F. Shortridge, K. Y. Yuen, J. S.M. Peiris, L. L.M. Poon

Research output: Contribution to journal › Article › peer-review

1901 Citations (Scopus)

Abstract

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

Original language	English
Pages (from-to)	276-278
Number of pages	3
Journal	Science
Volume	302
Issue number	5643
DOIs	https://doi.org/10.1126/science.1087139
Publication status	Published - Oct 10 2003
Externally published	Yes

ASJC Scopus Subject Areas

General

Access to Document

10.1126/science.1087139

Cite this

Guan, Y., Zheng, B. J., He, Y. Q., Liu, X. L., Zhuang, Z. X., Cheung, C. L., Luo, S. W., Li, P. H., Zhang, L. J., Guan, Y. J., Butt, K. M., Wong, K. L., Chan, K. W., Lim, W., Shortridge, K. F., Yuen, K. Y., Peiris, J. S. M., & Poon, L. L. M. (2003). Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China. Science, 302(5643), 276-278. https://doi.org/10.1126/science.1087139

Guan, Y, Zheng, BJ, He, YQ, Liu, XL, Zhuang, ZX, Cheung, CL, Luo, SW, Li, PH, Zhang, LJ, Guan, YJ, Butt, KM, Wong, KL, Chan, KW, Lim, W, Shortridge, KF, Yuen, KY, Peiris, JSM & Poon, LLM 2003, 'Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China', Science, vol. 302, no. 5643, pp. 276-278. https://doi.org/10.1126/science.1087139

@article{81e355174b64430aab174563d44574d5,

title = "Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China",

abstract = "A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.",

author = "Y. Guan and Zheng, {B. J.} and He, {Y. Q.} and Liu, {X. L.} and Zhuang, {Z. X.} and Cheung, {C. L.} and Luo, {S. W.} and Li, {P. H.} and Zhang, {L. J.} and Guan, {Y. J.} and Butt, {K. M.} and Wong, {K. L.} and Chan, {K. W.} and W. Lim and Shortridge, {K. F.} and Yuen, {K. Y.} and Peiris, {J. S.M.} and Poon, {L. L.M.}",

year = "2003",

month = oct,

day = "10",

doi = "10.1126/science.1087139",

language = "English",

volume = "302",

pages = "276--278",

journal = "Science",

issn = "0036-8075",

number = "5643",

}

TY - JOUR

T1 - Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China

AU - Guan, Y.

AU - Zheng, B. J.

AU - He, Y. Q.

AU - Liu, X. L.

AU - Zhuang, Z. X.

AU - Cheung, C. L.

AU - Luo, S. W.

AU - Li, P. H.

AU - Zhang, L. J.

AU - Guan, Y. J.

AU - Butt, K. M.

AU - Wong, K. L.

AU - Chan, K. W.

AU - Lim, W.

AU - Shortridge, K. F.

AU - Yuen, K. Y.

AU - Peiris, J. S.M.

AU - Poon, L. L.M.

PY - 2003/10/10

Y1 - 2003/10/10

N2 - A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

AB - A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

UR - http://www.scopus.com/inward/record.url?scp=0141889936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141889936&partnerID=8YFLogxK

U2 - 10.1126/science.1087139

DO - 10.1126/science.1087139

M3 - Article

C2 - 12958366

AN - SCOPUS:0141889936

SN - 0036-8075

VL - 302

SP - 276

EP - 278

JO - Science

JF - Science

IS - 5643

ER -

Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China

Abstract

ASJC Scopus Subject Areas

Access to Document

Other files and links

Cite this