Infection of immunocompromised patients by avian H9N2 influenza A virus

Vincent C.C. Cheng; Jasper F.W. Chan; X. Wen; W. L. Wu; T. L. Que; H. Chen; K. H. Chan; K. Y. Yuen

doi:10.1016/j.jinf.2011.02.007

Infection of immunocompromised patients by avian H9N2 influenza A virus

Vincent C.C. Cheng, Jasper F.W. Chan, X. Wen, W. L. Wu, T. L. Que, H. Chen, K. H. Chan, K. Y. Yuen

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted.

Original language	English
Pages (from-to)	394-399
Number of pages	6
Journal	Journal of Infection
Volume	62
Issue number	5
DOIs	https://doi.org/10.1016/j.jinf.2011.02.007
Publication status	Published - May 2011
Externally published	Yes

ASJC Scopus Subject Areas

Microbiology (medical)
Infectious Diseases

Keywords

Avian influenza A H9N2
Bone marrow transplantation
Immunocompromised host

Access to Document

10.1016/j.jinf.2011.02.007

Cite this

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title = "Infection of immunocompromised patients by avian H9N2 influenza A virus",

abstract = "Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted.",

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AU - Cheng, Vincent C.C.

AU - Chan, Jasper F.W.

AU - Wen, X.

AU - Wu, W. L.

AU - Que, T. L.

AU - Chen, H.

AU - Chan, K. H.

AU - Yuen, K. Y.

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N2 - Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted.

AB - Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted.

KW - Avian influenza A H9N2

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Infection of immunocompromised patients by avian H9N2 influenza A virus

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

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