Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus

Xiaoyu Zhao; Cun Li; Xiaojuan Liu; Man Chun Chiu; Dong Wang; Yuxuan Wei; Hin Chu; Jian Piao Cai; Ivy Hau-Yee Chan; Kenneth Kak-Yuen Wong; Jasper Fuk-Woo Chan; Kelvin Kai-Wang To; Kwok Yung Yuen; Jie Zhou

doi:10.1016/j.stemcr.2021.02.009

Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus

Xiaoyu Zhao, Cun Li, Xiaojuan Liu, Man Chun Chiu, Dong Wang, Yuxuan Wei, Hin Chu, Jian Piao Cai, Ivy Hau-Yee Chan, Kenneth Kak-Yuen Wong, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Kwok Yung Yuen, Jie Zhou

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Zhao and colleagues modified the composition of differentiation medium and demonstrated that the optimized medium improves the maturation state of human intestinal organoids. Two coronaviruses, SARS-CoV-2 and SARS-CoV, and two enteroviruses, EV-A71 and CVA16, reveal distinct profiles of virus-host interaction in the optimized intestinal organoids. Overall, human intestinal organoids adequately recapitulate disparate pathogenicity of coronaviruses and enteroviruses in the human intestines.

Original language	English
Pages (from-to)	493-504
Number of pages	12
Journal	Stem Cell Reports
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.stemcr.2021.02.009
Publication status	Published - Mar 9 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors

ASJC Scopus Subject Areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

Keywords

CVA16
EV-A71
intestinal organoids
pathogenicity
SARS-CoV
SARS-CoV-2

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10.1016/j.stemcr.2021.02.009

Cite this

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title = "Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus",

abstract = "Zhao and colleagues modified the composition of differentiation medium and demonstrated that the optimized medium improves the maturation state of human intestinal organoids. Two coronaviruses, SARS-CoV-2 and SARS-CoV, and two enteroviruses, EV-A71 and CVA16, reveal distinct profiles of virus-host interaction in the optimized intestinal organoids. Overall, human intestinal organoids adequately recapitulate disparate pathogenicity of coronaviruses and enteroviruses in the human intestines.",

keywords = "CVA16, EV-A71, intestinal organoids, pathogenicity, SARS-CoV, SARS-CoV-2",

author = "Xiaoyu Zhao and Cun Li and Xiaojuan Liu and Chiu, {Man Chun} and Dong Wang and Yuxuan Wei and Hin Chu and Cai, {Jian Piao} and {Hau-Yee Chan}, Ivy and {Kak-Yuen Wong}, Kenneth and {Fuk-Woo Chan}, Jasper and {Kai-Wang To}, Kelvin and Yuen, {Kwok Yung} and Jie Zhou",

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year = "2021",

month = mar,

day = "9",

doi = "10.1016/j.stemcr.2021.02.009",

language = "English",

volume = "16",

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journal = "Stem Cell Reports",

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T1 - Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus

AU - Zhao, Xiaoyu

AU - Li, Cun

AU - Liu, Xiaojuan

AU - Chiu, Man Chun

AU - Wang, Dong

AU - Wei, Yuxuan

AU - Chu, Hin

AU - Cai, Jian Piao

AU - Hau-Yee Chan, Ivy

AU - Kak-Yuen Wong, Kenneth

AU - Fuk-Woo Chan, Jasper

AU - Kai-Wang To, Kelvin

AU - Yuen, Kwok Yung

AU - Zhou, Jie

PY - 2021/3/9

Y1 - 2021/3/9

N2 - Zhao and colleagues modified the composition of differentiation medium and demonstrated that the optimized medium improves the maturation state of human intestinal organoids. Two coronaviruses, SARS-CoV-2 and SARS-CoV, and two enteroviruses, EV-A71 and CVA16, reveal distinct profiles of virus-host interaction in the optimized intestinal organoids. Overall, human intestinal organoids adequately recapitulate disparate pathogenicity of coronaviruses and enteroviruses in the human intestines.

AB - Zhao and colleagues modified the composition of differentiation medium and demonstrated that the optimized medium improves the maturation state of human intestinal organoids. Two coronaviruses, SARS-CoV-2 and SARS-CoV, and two enteroviruses, EV-A71 and CVA16, reveal distinct profiles of virus-host interaction in the optimized intestinal organoids. Overall, human intestinal organoids adequately recapitulate disparate pathogenicity of coronaviruses and enteroviruses in the human intestines.

KW - CVA16

KW - EV-A71

KW - intestinal organoids

KW - pathogenicity

KW - SARS-CoV

KW - SARS-CoV-2

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Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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