TY - JOUR
T1 - Host genes and influenza pathogenesis in humans
T2 - An emerging paradigm
AU - To, Kelvin Kai Wang
AU - Zhou, Jie
AU - Chan, Jasper Fuk Woo
AU - Yuen, Kwok Yung
N1 - Publisher Copyright:
© 2015 Published by Elsevier B.V.
PY - 2015/6/15
Y1 - 2015/6/15
N2 - The emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to seasonal influenza viruses. High-throughput screening platforms and large human or animal databases from international collaborations allow rapid selection of potential candidate genes for confirmatory functional studies. In the last 2 years, at least seven new human susceptibility genes have been identified in genetic association studies. Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection.
AB - The emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to seasonal influenza viruses. High-throughput screening platforms and large human or animal databases from international collaborations allow rapid selection of potential candidate genes for confirmatory functional studies. In the last 2 years, at least seven new human susceptibility genes have been identified in genetic association studies. Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection.
UR - http://www.scopus.com/inward/record.url?scp=84931268907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931268907&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2015.04.010
DO - 10.1016/j.coviro.2015.04.010
M3 - Review article
C2 - 26079652
AN - SCOPUS:84931268907
SN - 1879-6257
VL - 14
SP - 7
EP - 15
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -