Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

S. S.C. Chim; S. K.W. Tsui; K. C.A. Chan; T. C.C. Au; E. C.W. Hung; Y. K. Tong; R. W.K. Chiu; E. K.O. Ng; P. K.S. Chan; C. M. Chu; J. J.Y. Sung; J. S. Tam; K. P. Fung; M. M.Y. Waye; C. Y. Lee; K. Y. Yuen; Y. M.D. Lo

doi:10.1016/S0140-6736(03)14901-X

Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

S. S.C. Chim, S. K.W. Tsui, K. C.A. Chan, T. C.C. Au, E. C.W. Hung, Y. K. Tong, R. W.K. Chiu, E. K.O. Ng, P. K.S. Chan, C. M. Chu, J. J.Y. Sung, J. S. Tam, K. P. Fung, M. M.Y. Waye, C. Y. Lee, K. Y. Yuen, Y. M.D. Lo

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.

Original language	English
Pages (from-to)	1807-1808
Number of pages	2
Journal	Lancet
Volume	362
Issue number	9398
DOIs	https://doi.org/10.1016/S0140-6736(03)14901-X
Publication status	Published - Nov 29 2003
Externally published	Yes

ASJC Scopus Subject Areas

General Medicine

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10.1016/S0140-6736(03)14901-X

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Chim, S. S. C., Tsui, S. K. W., Chan, K. C. A., Au, T. C. C., Hung, E. C. W., Tong, Y. K., Chiu, R. W. K., Ng, E. K. O., Chan, P. K. S., Chu, C. M., Sung, J. J. Y., Tam, J. S., Fung, K. P., Waye, M. M. Y., Lee, C. Y., Yuen, K. Y., & Lo, Y. M. D. (2003). Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong. Lancet, 362(9398), 1807-1808. https://doi.org/10.1016/S0140-6736(03)14901-X

Chim, SSC, Tsui, SKW, Chan, KCA, Au, TCC, Hung, ECW, Tong, YK, Chiu, RWK, Ng, EKO, Chan, PKS, Chu, CM, Sung, JJY, Tam, JS, Fung, KP, Waye, MMY, Lee, CY, Yuen, KY & Lo, YMD 2003, 'Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong', Lancet, vol. 362, no. 9398, pp. 1807-1808. https://doi.org/10.1016/S0140-6736(03)14901-X

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title = "Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong",

abstract = "Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.",

author = "Chim, {S. S.C.} and Tsui, {S. K.W.} and Chan, {K. C.A.} and Au, {T. C.C.} and Hung, {E. C.W.} and Tong, {Y. K.} and Chiu, {R. W.K.} and Ng, {E. K.O.} and Chan, {P. K.S.} and Chu, {C. M.} and Sung, {J. J.Y.} and Tam, {J. S.} and Fung, {K. P.} and Waye, {M. M.Y.} and Lee, {C. Y.} and Yuen, {K. Y.} and Lo, {Y. M.D.}",

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doi = "10.1016/S0140-6736(03)14901-X",

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AU - Chim, S. S.C.

AU - Tsui, S. K.W.

AU - Chan, K. C.A.

AU - Au, T. C.C.

AU - Hung, E. C.W.

AU - Tong, Y. K.

AU - Chiu, R. W.K.

AU - Ng, E. K.O.

AU - Chan, P. K.S.

AU - Chu, C. M.

AU - Sung, J. J.Y.

AU - Tam, J. S.

AU - Fung, K. P.

AU - Waye, M. M.Y.

AU - Lee, C. Y.

AU - Yuen, K. Y.

AU - Lo, Y. M.D.

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N2 - Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.

AB - Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.

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Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong

Abstract

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