False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine

Kelvin Kai Wang To; Xin Li; David Christopher Lung; Jonathan Daniel Ip; Wan Mui Chan; Allen Wing Ho Chu; Cyril Chik Yan Yip; Jonathan H.K. Chen; Rosana Wing Shan Poon; Hoi Wah Tsoi; Raymond Wai Man Lai; Wing Kin To; Lili Ren; Mingkun Li; Yunlong Cao; Xiaoliang Sunney Xie; Dong Yan Jin; Kwok Yung Yuen

doi:10.1093/cid/ciab684

False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine

Kelvin Kai Wang To, Xin Li, David Christopher Lung, Jonathan Daniel Ip, Wan Mui Chan, Allen Wing Ho Chu, Cyril Chik Yan Yip, Jonathan H.K. Chen, Rosana Wing Shan Poon, Hoi Wah Tsoi, Raymond Wai Man Lai, Wing Kin To, Lili Ren, Mingkun Li, Yunlong Cao, Xiaoliang Sunney Xie, Dong Yan Jin, Kwok Yung Yuen

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A false-positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction result can lead to unnecessary public health measures. We report 2 individuals whose respiratory specimens were contaminated by an inactivated SARS-CoV-2 vaccine strain (CoronaVac), likely at vaccination premises. Incidentally, whole genome sequencing of CoronaVac showed adaptive deletions on the spike protein, which do not result in observable changes of antigenicity.

Original language	English
Pages (from-to)	1485-1488
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	74
Issue number	8
DOIs	https://doi.org/10.1093/cid/ciab684
Publication status	Published - Apr 15 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2021.

ASJC Scopus Subject Areas

Microbiology (medical)
Infectious Diseases

Keywords

contamination
false positive
inactivated COVID-19 vaccine

Access to Document

10.1093/cid/ciab684

Cite this

To, K. K. W., Li, X., Lung, D. C., Ip, J. D., Chan, W. M., Chu, A. W. H., Yip, C. C. Y., Chen, J. H. K., Poon, R. W. S., Tsoi, H. W., Lai, R. W. M., To, W. K., Ren, L., Li, M., Cao, Y., Xie, X. S., Jin, D. Y., & Yuen, K. Y. (2022). False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine. Clinical Infectious Diseases, 74(8), 1485-1488. https://doi.org/10.1093/cid/ciab684

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abstract = "A false-positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction result can lead to unnecessary public health measures. We report 2 individuals whose respiratory specimens were contaminated by an inactivated SARS-CoV-2 vaccine strain (CoronaVac), likely at vaccination premises. Incidentally, whole genome sequencing of CoronaVac showed adaptive deletions on the spike protein, which do not result in observable changes of antigenicity.",

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doi = "10.1093/cid/ciab684",

language = "English",

volume = "74",

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AU - To, Kelvin Kai Wang

AU - Li, Xin

AU - Lung, David Christopher

AU - Ip, Jonathan Daniel

AU - Chan, Wan Mui

AU - Chu, Allen Wing Ho

AU - Yip, Cyril Chik Yan

AU - Chen, Jonathan H.K.

AU - Poon, Rosana Wing Shan

AU - Tsoi, Hoi Wah

AU - Lai, Raymond Wai Man

AU - To, Wing Kin

AU - Ren, Lili

AU - Li, Mingkun

AU - Cao, Yunlong

AU - Xie, Xiaoliang Sunney

AU - Jin, Dong Yan

AU - Yuen, Kwok Yung

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AB - A false-positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction result can lead to unnecessary public health measures. We report 2 individuals whose respiratory specimens were contaminated by an inactivated SARS-CoV-2 vaccine strain (CoronaVac), likely at vaccination premises. Incidentally, whole genome sequencing of CoronaVac showed adaptive deletions on the spike protein, which do not result in observable changes of antigenicity.

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False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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