Emergence of a severe acute respiratory syndrome coronavirus 2 virus variant with novel genomic architecture in hong kong

Herman Tse; David Christopher Lung; Sally Cheuk Ying Wong; Ka Fai Ip; Tak Chiu Wu; Kelvin Kai Wang To; Kin Hang Kok; Kwok Yung Yuen; Garnet Kwan Yue Choi

doi:10.1093/cid/ciab198

Emergence of a severe acute respiratory syndrome coronavirus 2 virus variant with novel genomic architecture in hong kong

Herman Tse, David Christopher Lung, Sally Cheuk Ying Wong, Ka Fai Ip, Tak Chiu Wu, Kelvin Kai Wang To, Kin Hang Kok, Kwok Yung Yuen, Garnet Kwan Yue Choi

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Throughout the coronavirus disease 2019 (COVID-19) pandemic, divergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b, and ORF8, and a C-terminally modified ORF6 product resulting from partial 5′-untranslated region (UTR) duplication and transposition.

Original language	English
Pages (from-to)	1696-1699
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	73
Issue number	9
DOIs	https://doi.org/10.1093/cid/ciab198
Publication status	Published - Nov 1 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: Journals.permissions@oup.com.

ASJC Scopus Subject Areas

Microbiology (medical)
Infectious Diseases

Keywords

COVID-19
Genomic rearrangement
SARS-CoV-2
Whole-genome sequencing

Access to Document

10.1093/cid/ciab198

Cite this

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abstract = "Throughout the coronavirus disease 2019 (COVID-19) pandemic, divergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b, and ORF8, and a C-terminally modified ORF6 product resulting from partial 5′-untranslated region (UTR) duplication and transposition.",

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doi = "10.1093/cid/ciab198",

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AU - Tse, Herman

AU - Lung, David Christopher

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AU - Ip, Ka Fai

AU - Wu, Tak Chiu

AU - To, Kelvin Kai Wang

AU - Kok, Kin Hang

AU - Yuen, Kwok Yung

AU - Choi, Garnet Kwan Yue

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N2 - Throughout the coronavirus disease 2019 (COVID-19) pandemic, divergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b, and ORF8, and a C-terminally modified ORF6 product resulting from partial 5′-untranslated region (UTR) duplication and transposition.

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Emergence of a severe acute respiratory syndrome coronavirus 2 virus variant with novel genomic architecture in hong kong

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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