Distribution of amantadine-resistant H5N1 avian influenza variants in Asia

Chung Lam Cheung; Jane M. Rayner; Gavin J.D. Smith; Pui Wang; T. S.P. Naipospos; Jinxia Zhang; Kwok Yung Yuen; Robert G. Webster; J. S.Malik Peiris; Yi Guan; Honglin Chen

doi:10.1086/504723

Distribution of amantadine-resistant H5N1 avian influenza variants in Asia

Chung Lam Cheung, Jane M. Rayner, Gavin J.D. Smith, Pui Wang, T. S.P. Naipospos, Jinxia Zhang, Kwok Yung Yuen, Robert G. Webster, J. S.Malik Peiris, Yi Guan, Honglin Chen

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256 Citations (Scopus)

Abstract

We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine→isoleucine at aa 26 and serine→asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations.

Original language	English
Pages (from-to)	1626-1629
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	193
Issue number	12
DOIs	https://doi.org/10.1086/504723
Publication status	Published - Jun 15 2006
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

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10.1086/504723

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title = "Distribution of amantadine-resistant H5N1 avian influenza variants in Asia",

abstract = "We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine→isoleucine at aa 26 and serine→asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations.",

author = "Cheung, {Chung Lam} and Rayner, {Jane M.} and Smith, {Gavin J.D.} and Pui Wang and Naipospos, {T. S.P.} and Jinxia Zhang and Yuen, {Kwok Yung} and Webster, {Robert G.} and Peiris, {J. S.Malik} and Yi Guan and Honglin Chen",

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AU - Cheung, Chung Lam

AU - Rayner, Jane M.

AU - Smith, Gavin J.D.

AU - Wang, Pui

AU - Naipospos, T. S.P.

AU - Zhang, Jinxia

AU - Yuen, Kwok Yung

AU - Webster, Robert G.

AU - Peiris, J. S.Malik

AU - Guan, Yi

AU - Chen, Honglin

PY - 2006/6/15

Y1 - 2006/6/15

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AB - We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine→isoleucine at aa 26 and serine→asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations.

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Distribution of amantadine-resistant H5N1 avian influenza variants in Asia

Abstract

ASJC Scopus Subject Areas

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