Development of anti-influenza A compounds: a pilot study.

B. J. Zheng; C. S. Chan; K. M. Poon; F. Ng; C. M. Ho; C. M. Che; K. Y. Yuen

Development of anti-influenza A compounds: a pilot study.

B. J. Zheng, C. S. Chan, K. M. Poon, F. Ng, C. M. Ho, C. M. Che, K. Y. Yuen

School of nursing

Research output: Contribution to journal › Article › peer-review

Abstract

1. There is no effective anti-H5N1 avian influenza agent. 2. A chemical compound- BFDBSC-can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues. 3. This pilot study assessed anti- H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system. 4. Two compounds-FPBFDBSC and BFB-gallate- showed higher antiviral effectsthan BFDBSC, whearas the other two-BFB-borneol and BFB-menthol-showed lower antiviral effects. These compounds did not show toxicity. 5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility

Original language	English
Pages (from-to)	36-38
Number of pages	3
Journal	Hong Kong Medical Journal
Volume	19 Suppl 4
Publication status	Published - Jun 2013

ASJC Scopus Subject Areas

General Medicine

Cite this

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title = "Development of anti-influenza A compounds: a pilot study.",

abstract = "1. There is no effective anti-H5N1 avian influenza agent. 2. A chemical compound- BFDBSC-can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues. 3. This pilot study assessed anti- H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system. 4. Two compounds-FPBFDBSC and BFB-gallate- showed higher antiviral effectsthan BFDBSC, whearas the other two-BFB-borneol and BFB-menthol-showed lower antiviral effects. These compounds did not show toxicity. 5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility",

author = "Zheng, {B. J.} and Chan, {C. S.} and Poon, {K. M.} and F. Ng and Ho, {C. M.} and Che, {C. M.} and Yuen, {K. Y.}",

year = "2013",

month = jun,

language = "English",

volume = "19 Suppl 4",

pages = "36--38",

journal = "Hong Kong Medical Journal",

issn = "1024-2708",

publisher = "Hong Kong Academy of Medicine Press",

}

TY - JOUR

T1 - Development of anti-influenza A compounds

T2 - a pilot study.

AU - Zheng, B. J.

AU - Chan, C. S.

AU - Poon, K. M.

AU - Ng, F.

AU - Ho, C. M.

AU - Che, C. M.

AU - Yuen, K. Y.

PY - 2013/6

Y1 - 2013/6

N2 - 1. There is no effective anti-H5N1 avian influenza agent. 2. A chemical compound- BFDBSC-can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues. 3. This pilot study assessed anti- H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system. 4. Two compounds-FPBFDBSC and BFB-gallate- showed higher antiviral effectsthan BFDBSC, whearas the other two-BFB-borneol and BFB-menthol-showed lower antiviral effects. These compounds did not show toxicity. 5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility

AB - 1. There is no effective anti-H5N1 avian influenza agent. 2. A chemical compound- BFDBSC-can inhibit H5N1 virus infection in cell cultures, and such inhibition might be attributable to its halogenated benzoyl residues. 3. This pilot study assessed anti- H5N1 activity and toxicity of four chemical compounds with halogenated benzoyl residues in cell culture system. 4. Two compounds-FPBFDBSC and BFB-gallate- showed higher antiviral effectsthan BFDBSC, whearas the other two-BFB-borneol and BFB-menthol-showed lower antiviral effects. These compounds did not show toxicity. 5. The halogenated benzoyl residues may play a key role in anti-H5N1 effects. However, all these compounds showed poor solubility, which may limit their utility

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SN - 1024-2708

VL - 19 Suppl 4

SP - 36

EP - 38

JO - Hong Kong Medical Journal

JF - Hong Kong Medical Journal

ER -

Development of anti-influenza A compounds: a pilot study.

Abstract

ASJC Scopus Subject Areas

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