Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities

Xin Li; Jacky Man Chun Chan; Bosco Lam; David Christopher Lung; Kwok Cheung Lung; Christina Kin Yi Chow; Tracey Tam; Kelvin Hei Yeung Chiu; Ling Lung Hung; Ivan Fan Ngai Hung; Vincent Chi Chung Cheng; Kelvin Kai Wang To; Kwok Yung Yuen

doi:10.1093/cid/ciab1062

Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities

Xin Li, Jacky Man Chun Chan, Bosco Lam, David Christopher Lung, Kwok Cheung Lung, Christina Kin Yi Chow, Tracey Tam, Kelvin Hei Yeung Chiu, Ling Lung Hung, Ivan Fan Ngai Hung, Vincent Chi Chung Cheng, Kelvin Kai Wang To, Kwok Yung Yuen

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This retrospective study of incoming travelers with coronavirus disease 2019 showed that individuals immunized by messenger RNA vaccines had significantly longer postvaccination intervals (median, 30.5 days) to breakthrough infection, lower white blood cell counts and lactate dehydrogenase levels on admission, and fewer radiographic abnormalities than those immunized by inactivated virus vaccine, who paradoxically had lower respiratory viral load.

Original language	English
Pages (from-to)	E905-E908
Journal	Clinical Infectious Diseases
Volume	75
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciab1062
Publication status	Published - Jul 1 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

ASJC Scopus Subject Areas

Microbiology (medical)
Infectious Diseases

Keywords

COVID-19
inactivated whole-virus vaccine
mRNA vaccine
vaccine breakthrough infection

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10.1093/cid/ciab1062

Cite this

Li, X., Chan, J. M. C., Lam, B., Lung, D. C., Lung, K. C., Chow, C. K. Y., Tam, T., Chiu, K. H. Y., Hung, L. L., Hung, I. F. N., Cheng, V. C. C., To, K. K. W., & Yuen, K. Y. (2022). Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities. Clinical Infectious Diseases, 75(1), E905-E908. https://doi.org/10.1093/cid/ciab1062

Li, X, Chan, JMC, Lam, B, Lung, DC, Lung, KC, Chow, CKY, Tam, T, Chiu, KHY, Hung, LL, Hung, IFN, Cheng, VCC, To, KKW & Yuen, KY 2022, 'Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities', Clinical Infectious Diseases, vol. 75, no. 1, pp. E905-E908. https://doi.org/10.1093/cid/ciab1062

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abstract = "This retrospective study of incoming travelers with coronavirus disease 2019 showed that individuals immunized by messenger RNA vaccines had significantly longer postvaccination intervals (median, 30.5 days) to breakthrough infection, lower white blood cell counts and lactate dehydrogenase levels on admission, and fewer radiographic abnormalities than those immunized by inactivated virus vaccine, who paradoxically had lower respiratory viral load.",

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author = "Xin Li and Chan, {Jacky Man Chun} and Bosco Lam and Lung, {David Christopher} and Lung, {Kwok Cheung} and Chow, {Christina Kin Yi} and Tracey Tam and Chiu, {Kelvin Hei Yeung} and Hung, {Ling Lung} and Hung, {Ivan Fan Ngai} and Cheng, {Vincent Chi Chung} and To, {Kelvin Kai Wang} and Yuen, {Kwok Yung}",

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doi = "10.1093/cid/ciab1062",

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AU - Li, Xin

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AU - Lam, Bosco

AU - Lung, David Christopher

AU - Lung, Kwok Cheung

AU - Chow, Christina Kin Yi

AU - Tam, Tracey

AU - Chiu, Kelvin Hei Yeung

AU - Hung, Ling Lung

AU - Hung, Ivan Fan Ngai

AU - Cheng, Vincent Chi Chung

AU - To, Kelvin Kai Wang

AU - Yuen, Kwok Yung

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N2 - This retrospective study of incoming travelers with coronavirus disease 2019 showed that individuals immunized by messenger RNA vaccines had significantly longer postvaccination intervals (median, 30.5 days) to breakthrough infection, lower white blood cell counts and lactate dehydrogenase levels on admission, and fewer radiographic abnormalities than those immunized by inactivated virus vaccine, who paradoxically had lower respiratory viral load.

AB - This retrospective study of incoming travelers with coronavirus disease 2019 showed that individuals immunized by messenger RNA vaccines had significantly longer postvaccination intervals (median, 30.5 days) to breakthrough infection, lower white blood cell counts and lactate dehydrogenase levels on admission, and fewer radiographic abnormalities than those immunized by inactivated virus vaccine, who paradoxically had lower respiratory viral load.

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KW - inactivated whole-virus vaccine

KW - mRNA vaccine

KW - vaccine breakthrough infection

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Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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