Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment

Jaime S. Rosa Duque; Kelvin K.W. To; Alan K.S. Chiang; Godfrey C.F. Chan; Rosana W.S. Poon; Kwok Yung Yuen; Shau Yin Ha; Daniel K.L. Cheuk

doi:10.1016/j.ijid.2019.02.002

Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment

Jaime S. Rosa Duque, Kelvin K.W. To, Alan K.S. Chiang, Godfrey C.F. Chan, Rosana W.S. Poon, Kwok Yung Yuen, Shau Yin Ha, Daniel K.L. Cheuk

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	International Journal of Infectious Diseases
Volume	81
DOIs	https://doi.org/10.1016/j.ijid.2019.02.002
Publication status	Published - Apr 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

ASJC Scopus Subject Areas

Microbiology (medical)
Infectious Diseases

Keywords

Candida
Leukemia
Nucleic acid amplification
Polymerase chain reaction
Renal abscess

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10.1016/j.ijid.2019.02.002

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Rosa Duque, J. S., To, K. K. W., Chiang, A. K. S., Chan, G. C. F., Poon, R. W. S., Yuen, K. Y., Ha, S. Y., & Cheuk, D. K. L. (2019). Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment. International Journal of Infectious Diseases, 81, 110-113. https://doi.org/10.1016/j.ijid.2019.02.002

Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment. / Rosa Duque, Jaime S.; To, Kelvin K.W.; Chiang, Alan K.S. et al.
In: International Journal of Infectious Diseases, Vol. 81, 04.2019, p. 110-113.

Research output: Contribution to journal › Article › peer-review

Rosa Duque, JS, To, KKW, Chiang, AKS, Chan, GCF, Poon, RWS, Yuen, KY, Ha, SY & Cheuk, DKL 2019, 'Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment', International Journal of Infectious Diseases, vol. 81, pp. 110-113. https://doi.org/10.1016/j.ijid.2019.02.002

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title = "Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment",

abstract = "We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy.",

keywords = "Candida, Leukemia, Nucleic acid amplification, Polymerase chain reaction, Renal abscess",

author = "{Rosa Duque}, {Jaime S.} and To, {Kelvin K.W.} and Chiang, {Alan K.S.} and Chan, {Godfrey C.F.} and Poon, {Rosana W.S.} and Yuen, {Kwok Yung} and Ha, {Shau Yin} and Cheuk, {Daniel K.L.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

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doi = "10.1016/j.ijid.2019.02.002",

language = "English",

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AU - Rosa Duque, Jaime S.

AU - To, Kelvin K.W.

AU - Chiang, Alan K.S.

AU - Chan, Godfrey C.F.

AU - Poon, Rosana W.S.

AU - Yuen, Kwok Yung

AU - Ha, Shau Yin

AU - Cheuk, Daniel K.L.

PY - 2019/4

Y1 - 2019/4

N2 - We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy.

AB - We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy.

KW - Candida

KW - Leukemia

KW - Nucleic acid amplification

KW - Polymerase chain reaction

KW - Renal abscess

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Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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