Bacteremia due to Clostridium hathewayi in a patient with acute appendicitis

Patrick C.Y. Woo; Susanna K.P. Lau; Gibson K.S. Woo; Ami M.Y. Fung; Viola P.Y. Yiu; Kwok Yung Yuen

doi:10.1128/JCM.42.12.5947-5949.2004

Bacteremia due to Clostridium hathewayi in a patient with acute appendicitis

Patrick C.Y. Woo, Susanna K.P. Lau, Gibson K.S. Woo, Ami M.Y. Fung, Viola P.Y. Yiu, Kwok Yung Yuen

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Clostridium hathewayi is a newly described Clostridium species isolated from the feces of healthy human individuals, but its clinical significance is not known. We describe a case of human infection associated with C. hathewayi. The bacterium (strain HKU18) was isolated from the blood culture of a 39-year-old patient with acute gangrenous appendicitis complicated by septic shock. The cells were strictly anaerobic, nonmotile rods that stained gram negative. Conventional phenotypic tests and commercial identification systems failed to identify HKU18 to the species level. 16S rRNA gene analysis showed 1.4% nucleotide difference between the sequence of HKU18 and that of C. hathewayi, indicating that HKU18 was a strain of C. hathewayi. The patient responded to appendectomy and antibiotic treatment. 16S rRNA gene sequencing would be useful in further characterizing the clinical disease spectrum of C. hathewayi.

Original language	English
Pages (from-to)	5947-5949
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	42
Issue number	12
DOIs	https://doi.org/10.1128/JCM.42.12.5947-5949.2004
Publication status	Published - Dec 2004
Externally published	Yes

ASJC Scopus Subject Areas

Microbiology (medical)

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10.1128/JCM.42.12.5947-5949.2004

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title = "Bacteremia due to Clostridium hathewayi in a patient with acute appendicitis",

abstract = "Clostridium hathewayi is a newly described Clostridium species isolated from the feces of healthy human individuals, but its clinical significance is not known. We describe a case of human infection associated with C. hathewayi. The bacterium (strain HKU18) was isolated from the blood culture of a 39-year-old patient with acute gangrenous appendicitis complicated by septic shock. The cells were strictly anaerobic, nonmotile rods that stained gram negative. Conventional phenotypic tests and commercial identification systems failed to identify HKU18 to the species level. 16S rRNA gene analysis showed 1.4% nucleotide difference between the sequence of HKU18 and that of C. hathewayi, indicating that HKU18 was a strain of C. hathewayi. The patient responded to appendectomy and antibiotic treatment. 16S rRNA gene sequencing would be useful in further characterizing the clinical disease spectrum of C. hathewayi.",

author = "Woo, {Patrick C.Y.} and Lau, {Susanna K.P.} and Woo, {Gibson K.S.} and Fung, {Ami M.Y.} and Yiu, {Viola P.Y.} and Yuen, {Kwok Yung}",

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AU - Woo, Patrick C.Y.

AU - Lau, Susanna K.P.

AU - Woo, Gibson K.S.

AU - Fung, Ami M.Y.

AU - Yiu, Viola P.Y.

AU - Yuen, Kwok Yung

PY - 2004/12

Y1 - 2004/12

N2 - Clostridium hathewayi is a newly described Clostridium species isolated from the feces of healthy human individuals, but its clinical significance is not known. We describe a case of human infection associated with C. hathewayi. The bacterium (strain HKU18) was isolated from the blood culture of a 39-year-old patient with acute gangrenous appendicitis complicated by septic shock. The cells were strictly anaerobic, nonmotile rods that stained gram negative. Conventional phenotypic tests and commercial identification systems failed to identify HKU18 to the species level. 16S rRNA gene analysis showed 1.4% nucleotide difference between the sequence of HKU18 and that of C. hathewayi, indicating that HKU18 was a strain of C. hathewayi. The patient responded to appendectomy and antibiotic treatment. 16S rRNA gene sequencing would be useful in further characterizing the clinical disease spectrum of C. hathewayi.

AB - Clostridium hathewayi is a newly described Clostridium species isolated from the feces of healthy human individuals, but its clinical significance is not known. We describe a case of human infection associated with C. hathewayi. The bacterium (strain HKU18) was isolated from the blood culture of a 39-year-old patient with acute gangrenous appendicitis complicated by septic shock. The cells were strictly anaerobic, nonmotile rods that stained gram negative. Conventional phenotypic tests and commercial identification systems failed to identify HKU18 to the species level. 16S rRNA gene analysis showed 1.4% nucleotide difference between the sequence of HKU18 and that of C. hathewayi, indicating that HKU18 was a strain of C. hathewayi. The patient responded to appendectomy and antibiotic treatment. 16S rRNA gene sequencing would be useful in further characterizing the clinical disease spectrum of C. hathewayi.

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ER -

Bacteremia due to Clostridium hathewayi in a patient with acute appendicitis

Abstract

ASJC Scopus Subject Areas

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