Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: A serological study

Shigui Yang; Yu Chen; Dawei Cui; Hangping Yao; Jianzhou Lou; Zhaoxia Huo; Guoliang Xie; Fei Yu; Shufa Zheng; Yida Yang; Yixin Zhu; Xiaoqing Lu; Xiaoli Liu; Siu Ying Lau; Jasper Fuk Woo Chan; Kelvin Kai Wang To; Kwok Yung Yuen; Honglin Chen; Lanjuan Li

doi:10.1093/infdis/jit430

Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: A serological study

Shigui Yang, Yu Chen, Dawei Cui, Hangping Yao, Jianzhou Lou, Zhaoxia Huo, Guoliang Xie, Fei Yu, Shufa Zheng, Yida Yang, Yixin Zhu, Xiaoqing Lu, Xiaoli Liu, Siu Ying Lau, Jasper Fuk Woo Chan, Kelvin Kai Wang To, Kwok Yung Yuen, Honglin Chen, Lanjuan Li

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

Abstract

Serological surveillance conducted in areas of an outbreak of influenza A(H7N9) infection in China found no seropositivity for antibodies specific for avian-origin influenza A(H7N9) among 1129 individuals of the general population, whereas >6% of 396 poultry workers were positive (on the basis of a hemagglutination inhibition titer of ≥ 80) for this subtype, confirming that infected poultry is the principal source of human infections and that subclinical infections are possible. Fourteen days after symptom onset, elevated levels of antibodies to A(H7N9) were found in 65.8% of patients (25/38) who survived but in only 28.6% of those (2/7) who died, suggesting that the presence of antibodies may improve clinical outcome in infected patients.

Original language	English
Pages (from-to)	265-269
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	209
Issue number	2
DOIs	https://doi.org/10.1093/infdis/jit430
Publication status	Published - Jan 15 2014
Externally published	Yes

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

Keywords

Antibodies
H1N1
H7N9
Influenza
Poultry workers
Serological surveillance

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10.1093/infdis/jit430

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Yang, S., Chen, Y., Cui, D., Yao, H., Lou, J., Huo, Z., Xie, G., Yu, F., Zheng, S., Yang, Y., Zhu, Y., Lu, X., Liu, X., Lau, S. Y., Chan, J. F. W., To, K. K. W., Yuen, K. Y., Chen, H., & Li, L. (2014). Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: A serological study. Journal of Infectious Diseases, 209(2), 265-269. https://doi.org/10.1093/infdis/jit430

Yang, S, Chen, Y, Cui, D, Yao, H, Lou, J, Huo, Z, Xie, G, Yu, F, Zheng, S, Yang, Y, Zhu, Y, Lu, X, Liu, X, Lau, SY, Chan, JFW, To, KKW, Yuen, KY, Chen, H & Li, L 2014, 'Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: A serological study', Journal of Infectious Diseases, vol. 209, no. 2, pp. 265-269. https://doi.org/10.1093/infdis/jit430

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abstract = "Serological surveillance conducted in areas of an outbreak of influenza A(H7N9) infection in China found no seropositivity for antibodies specific for avian-origin influenza A(H7N9) among 1129 individuals of the general population, whereas >6% of 396 poultry workers were positive (on the basis of a hemagglutination inhibition titer of ≥ 80) for this subtype, confirming that infected poultry is the principal source of human infections and that subclinical infections are possible. Fourteen days after symptom onset, elevated levels of antibodies to A(H7N9) were found in 65.8% of patients (25/38) who survived but in only 28.6% of those (2/7) who died, suggesting that the presence of antibodies may improve clinical outcome in infected patients.",

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AU - Li, Lanjuan

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Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: A serological study

Abstract

ASJC Scopus Subject Areas

Keywords

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