TY - JOUR
T1 - Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
AU - Cheung, Bernard M.Y.
AU - Ong, Kwok Leung
AU - Cheung, Roberta V.
AU - Wong, Louisa Y.F.
AU - Wat, Nelson M.S.
AU - Tam, Sidney
AU - Leung, Gabriel M.
AU - Cheng, Chun Ho
AU - Woo, Jean
AU - Janus, Edward D.
AU - Lau, Chu Pak
AU - Hing Lam, Tai
AU - Lam, Karen S.L.
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Background: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.
AB - Background: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.
KW - Alkaline phosphatase
KW - C-reactive protein
KW - Inflammation
KW - Liver
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U2 - 10.1515/CCLM.2008.111
DO - 10.1515/CCLM.2008.111
M3 - Article
C2 - 18605934
AN - SCOPUS:44949173227
SN - 1434-6621
VL - 46
SP - 523
EP - 527
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 4
ER -