TY - JOUR
T1 - An animal model of mers produced by infection of rhesus macaques with MERS coronavirus
AU - Yao, Yanfeng
AU - Bao, Linlin
AU - Deng, Wei
AU - Xu, Lili
AU - Li, Fengdi
AU - Lv, Qi
AU - Yu, Pin
AU - Chen, Ting
AU - Xu, Yanfeng
AU - Zhu, Hua
AU - Yuan, Jing
AU - Gu, Songzhi
AU - Wei, Qiang
AU - Chen, Honglin
AU - Yuen, Kwok Yung
AU - Qin, Chuan
PY - 2014/1/15
Y1 - 2014/1/15
N2 - In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
AB - In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
KW - Animal model
KW - Coronavirus
KW - MERS
KW - Pathology
KW - Rhesus monkey
UR - http://www.scopus.com/inward/record.url?scp=84891522722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891522722&partnerID=8YFLogxK
U2 - 10.1093/infdis/jit590
DO - 10.1093/infdis/jit590
M3 - Article
AN - SCOPUS:84891522722
SN - 0022-1899
VL - 209
SP - 236
EP - 242
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -