Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study

Shiu Lun Au Yeung; Chaoqiang Jiang; Kar Keung Cheng; Lin Xu; Weisen Zhang; Tai Hing Lam; Gabriel Matthew Leung; C. Mary Schooling

doi:10.1016/j.psychres.2017.09.040

Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study

Shiu Lun Au Yeung, Chaoqiang Jiang, Kar Keung Cheng, Lin Xu, Weisen Zhang, Tai Hing Lam, Gabriel Matthew Leung, C. Mary Schooling

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.

Original language	English
Pages (from-to)	32-35
Number of pages	4
Journal	Psychiatry Research
Volume	259
DOIs	https://doi.org/10.1016/j.psychres.2017.09.040
Publication status	Published - Jan 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

ASJC Scopus Subject Areas

Psychiatry and Mental health
Biological Psychiatry

Keywords

China
Epidemiology

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10.1016/j.psychres.2017.09.040

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title = "Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study",

abstract = "To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.",

keywords = "China, Epidemiology",

author = "{Au Yeung}, {Shiu Lun} and Chaoqiang Jiang and Cheng, {Kar Keung} and Lin Xu and Weisen Zhang and Lam, {Tai Hing} and Leung, {Gabriel Matthew} and Schooling, {C. Mary}",

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year = "2018",

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doi = "10.1016/j.psychres.2017.09.040",

language = "English",

volume = "259",

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T2 - A Mendelian randomization study in the Guangzhou Biobank Cohort Study

AU - Au Yeung, Shiu Lun

AU - Jiang, Chaoqiang

AU - Cheng, Kar Keung

AU - Xu, Lin

AU - Zhang, Weisen

AU - Lam, Tai Hing

AU - Leung, Gabriel Matthew

AU - Schooling, C. Mary

PY - 2018/1

Y1 - 2018/1

N2 - To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.

AB - To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.

KW - China

KW - Epidemiology

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UR - http://www.scopus.com/inward/citedby.url?scp=85030858863&partnerID=8YFLogxK

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SN - 0165-1781

VL - 259

SP - 32

EP - 35

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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