Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Runhong Zhou; Kelvin Kai Wang To; Yik Chun Wong; Li Liu; Biao Zhou; Xin Li; Haode Huang; Yufei Mo; Tsz Yat Luk; Thomas Tsz Kan Lau; Pauline Yeung; Wai Ming Chan; Alan Ka Lun Wu; Kwok Cheung Lung; Owen Tak Yin Tsang; Wai Shing Leung; Ivan Fan Ngai Hung; Kwok Yung Yuen; Zhiwei Chen

doi:10.1016/j.immuni.2020.07.026

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Runhong Zhou, Kelvin Kai Wang To, Yik Chun Wong, Li Liu, Biao Zhou, Xin Li, Haode Huang, Yufei Mo, Tsz Yat Luk, Thomas Tsz Kan Lau, Pauline Yeung, Wai Ming Chan, Alan Ka Lun Wu, Kwok Cheung Lung, Owen Tak Yin Tsang, Wai Shing Leung, Ivan Fan Ngai Hung, Kwok Yung Yuen, Zhiwei Chen

Research output: Contribution to journal › Article › peer-review

421 Citations (Scopus)

Abstract

COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.

Original language	English
Pages (from-to)	864-877.e5
Journal	Immunity
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2020.07.026
Publication status	Published - Oct 13 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Infectious Diseases

Keywords

COVID-19
SARS-CoV-2
T cell immune response
acute infection
convalescent
dendritic cell
neutralizing antibody
nucleocapsid protein
receptor-binding domain

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10.1016/j.immuni.2020.07.026

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Zhou, R., To, K. K. W., Wong, Y. C., Liu, L., Zhou, B., Li, X., Huang, H., Mo, Y., Luk, T. Y., Lau, T. T. K., Yeung, P., Chan, W. M., Wu, A. K. L., Lung, K. C., Tsang, O. T. Y., Leung, W. S., Hung, I. F. N., Yuen, K. Y., & Chen, Z. (2020). Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses. Immunity, 53(4), 864-877.e5. https://doi.org/10.1016/j.immuni.2020.07.026

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abstract = "COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.",

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AU - Zhou, Runhong

AU - To, Kelvin Kai Wang

AU - Wong, Yik Chun

AU - Liu, Li

AU - Zhou, Biao

AU - Li, Xin

AU - Huang, Haode

AU - Mo, Yufei

AU - Luk, Tsz Yat

AU - Lau, Thomas Tsz Kan

AU - Yeung, Pauline

AU - Chan, Wai Ming

AU - Wu, Alan Ka Lun

AU - Lung, Kwok Cheung

AU - Tsang, Owen Tak Yin

AU - Leung, Wai Shing

AU - Hung, Ivan Fan Ngai

AU - Yuen, Kwok Yung

AU - Chen, Zhiwei

PY - 2020/10/13

Y1 - 2020/10/13

N2 - COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.

AB - COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.

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KW - SARS-CoV-2

KW - T cell immune response

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KW - convalescent

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KW - neutralizing antibody

KW - nucleocapsid protein

KW - receptor-binding domain

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Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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