Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

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Abstract

COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.

Original language	English
Pages (from-to)	864-877.e5
Journal	Immunity
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2020.07.026
Publication status	Published - Oct 13 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology
Infectious Diseases

Keywords

COVID-19
SARS-CoV-2
T cell immune response
acute infection
convalescent
dendritic cell
neutralizing antibody
nucleocapsid protein
receptor-binding domain

Access to Document

10.1016/j.immuni.2020.07.026

Cite this

Zhou, R., To, K. K. W., Wong, Y. C., Liu, L., Zhou, B., Li, X., Huang, H., Mo, Y., Luk, T. Y., Lau, T. T. K., Yeung, P., Chan, W. M., Wu, A. K. L., Lung, K. C., Tsang, O. T. Y., Leung, W. S., Hung, I. F. N., Yuen, K. Y., & Chen, Z. (2020). Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses. Immunity, 53(4), 864-877.e5. https://doi.org/10.1016/j.immuni.2020.07.026

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abstract = "COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.",

keywords = "COVID-19, SARS-CoV-2, T cell immune response, acute infection, convalescent, dendritic cell, neutralizing antibody, nucleocapsid protein, receptor-binding domain",

author = "Runhong Zhou and To, {Kelvin Kai Wang} and Wong, {Yik Chun} and Li Liu and Biao Zhou and Xin Li and Haode Huang and Yufei Mo and Luk, {Tsz Yat} and Lau, {Thomas Tsz Kan} and Pauline Yeung and Chan, {Wai Ming} and Wu, {Alan Ka Lun} and Lung, {Kwok Cheung} and Tsang, {Owen Tak Yin} and Leung, {Wai Shing} and Hung, {Ivan Fan Ngai} and Yuen, {Kwok Yung} and Zhiwei Chen",

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T1 - Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

AU - Zhou, Runhong

AU - To, Kelvin Kai Wang

AU - Wong, Yik Chun

AU - Liu, Li

AU - Zhou, Biao

AU - Li, Xin

AU - Huang, Haode

AU - Mo, Yufei

AU - Luk, Tsz Yat

AU - Lau, Thomas Tsz Kan

AU - Yeung, Pauline

AU - Chan, Wai Ming

AU - Wu, Alan Ka Lun

AU - Lung, Kwok Cheung

AU - Tsang, Owen Tak Yin

AU - Leung, Wai Shing

AU - Hung, Ivan Fan Ngai

AU - Yuen, Kwok Yung

AU - Chen, Zhiwei

PY - 2020/10/13

Y1 - 2020/10/13

N2 - COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.

AB - COVID-19 is an acute disease caused by SARS-CoV-2 infection. We determine how the immune system responds to SARS-CoV-2 at both acute and convalescent stages. Acute SARS-CoV-2 infection results in broad immune cell reduction and functional impairment. While neutralizing antibodies are rapidly generated, antigen-specific T cells are delayed at the acute stage.

KW - COVID-19

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KW - T cell immune response

KW - acute infection

KW - convalescent

KW - dendritic cell

KW - neutralizing antibody

KW - nucleocapsid protein

KW - receptor-binding domain

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